CNTRL

Protein-coding gene in the species Homo sapiens
CNTRL
Identifiers
AliasesCNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDsOMIM: 605496; MGI: 1889576; HomoloGene: 38260; GeneCards: CNTRL; OMA:CNTRL - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CNTRL
Genomic location for CNTRL
Band9q33.2Start121,074,660 bp[1]
End121,177,729 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for CNTRL
Genomic location for CNTRL
Band2|2 BStart35,109,492 bp[2]
End35,178,822 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • secondary oocyte

  • bronchial epithelial cell

  • sural nerve

  • sperm

  • monocyte

  • right uterine tube

  • bone marrow cells

  • lymph node

  • superficial temporal artery
Top expressed in
  • spermatocyte

  • thymus

  • spermatid

  • spleen

  • blood

  • seminiferous tubule

  • ganglionic eminence

  • left lobe of liver

  • bone marrow

  • submandibular gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein tyrosine kinase activity
  • cytoskeletal protein binding
Cellular component
  • microtubule organizing center
  • centrosome
  • cytoskeleton
  • membrane
  • cytoplasm
  • cytosol
  • midbody
  • Flemming body
  • centriolar subdistal appendage
Biological process
  • cell division
  • cell cycle
  • G2/M transition of mitotic cell cycle
  • peptidyl-tyrosine phosphorylation
  • mitotic cell cycle
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
  • regulation of cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11064

26920

Ensembl

ENSG00000119397

ENSMUSG00000057110

UniProt

Q7Z7A1

A2AL36

RefSeq (mRNA)
NM_007018
NM_001330762
NM_001369892
NM_001369893
NM_001369894

NM_001369895
NM_001369896

NM_001290635
NM_012018
NM_030000
NM_001379274
NM_001379275

RefSeq (protein)
NP_001317691
NP_008949
NP_001356821
NP_001356822
NP_001356823

NP_001356824
NP_001356825

NP_001277564
NP_036148
NP_001366203
NP_001366204

Location (UCSC)Chr 9: 121.07 – 121.18 MbChr 2: 35.11 – 35.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.[5][6]

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119397 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057110 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. doi:10.1182/blood.V95.5.1788.005k15_1788_1796. PMID 10688839.
  6. ^ a b "Entrez Gene: CEP110 centrosomal protein 110kDa".

External links

Further reading

  • Gromley A, Yeaman C, Rosa J, et al. (2005). "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission". Cell. 123 (1): 75–87. doi:10.1016/j.cell.2005.07.027. PMID 16213214. S2CID 6665005.
  • Guinn BA, Bland EA, Lodi U, et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
  • Jurczyk A, Gromley A, Redick S, et al. (2004). "Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43. doi:10.1083/jcb.200405023. PMC 2172416. PMID 15337773.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gromley A, Jurczyk A, Sillibourne J, et al. (2003). "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase". J. Cell Biol. 161 (3): 535–45. doi:10.1083/jcb.200301105. PMC 2172935. PMID 12732615.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. doi:10.1242/jcs.115.9.1825. PMID 11956314.
  • Popovici C, Mattéi MG, Rattner JB, et al. (2000). "Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization". Cytogenet. Cell Genet. 89 (3–4): 216–7. doi:10.1159/000015616. PMID 10965126. S2CID 31717030.
  • Osaki E, Nishina Y, Inazawa J, et al. (1999). "Identification of a novel Sry-related gene and its germ cell-specific expression". Nucleic Acids Res. 27 (12): 2503–10. doi:10.1093/nar/27.12.2503. PMC 148454. PMID 10359848.
  • Schütze S, Machleidt T, Adam D, et al. (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. PMID 10187805.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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