CDC42EP3

Protein-coding gene in the species Homo sapiens
CDC42EP3
Identifiers
AliasesCDC42EP3, BORG2, CEP3, UB1, CDC42 effector protein 3
External IDsOMIM: 606133; MGI: 2384718; HomoloGene: 4708; GeneCards: CDC42EP3; OMA:CDC42EP3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CDC42EP3
Genomic location for CDC42EP3
Band2p22.2Start37,641,882 bp[1]
End37,738,468 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for CDC42EP3
Genomic location for CDC42EP3
Band17|17 E3Start79,641,156 bp[2]
End79,662,520 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • monocyte

  • seminal vesicula

  • myocardium of left ventricle

  • glomerulus

  • metanephric glomerulus

  • saphenous vein

  • right ventricle

  • tail of epididymis

  • myometrium
Top expressed in
  • spermatocyte

  • condyle

  • tibiofemoral joint

  • tunica media of zone of aorta

  • granulocyte

  • vas deferens

  • urinary bladder

  • seminiferous tubule

  • calvaria

  • ascending aorta
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • GTPase activator activity
  • cytoskeletal regulatory protein binding
  • protein binding
Cellular component
  • cytoplasm
  • cytosol
  • cytoskeleton
  • membrane
  • endomembrane system
  • actin cytoskeleton
  • plasma membrane
Biological process
  • positive regulation of pseudopodium assembly
  • positive regulation of actin filament polymerization
  • Rho protein signal transduction
  • signal transduction
  • regulation of cell shape
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10602

260409

Ensembl

ENSG00000163171

ENSMUSG00000036533

UniProt

Q9UKI2

Q9CQC5

RefSeq (mRNA)
NM_001270436
NM_001270437
NM_001270438
NM_006449
NM_001371569

NM_001371570

NM_026514

RefSeq (protein)
NP_001257365
NP_001257366
NP_001257367
NP_006440
NP_001358498

NP_001358499

NP_080790

Location (UCSC)Chr 2: 37.64 – 37.74 MbChr 17: 79.64 – 79.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.[5][6][7]

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.[7]

Interactions

CDC42EP3 has been shown to interact with CDC42[5][8] and RHOQ.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163171 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036533 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi:10.1074/jbc.273.15.8616. PMID 9535835.
  6. ^ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
  7. ^ a b "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
  8. ^ a b Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. ISSN 0270-7306. PMC 84628. PMID 10490598.

External links

Further reading

  • Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628. PMID 10490598.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Joberty G, Perlungher RR, Sheffield PJ, et al. (2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nat. Cell Biol. 3 (10): 861–6. doi:10.1038/ncb1001-861. PMID 11584266. S2CID 58805.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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