CALN1

Protein-coding gene in the species Homo sapiens
CALN1
Identifiers
AliasesCALN1, CABP8, calneuron 1
External IDsOMIM: 607176; MGI: 2155987; HomoloGene: 10966; GeneCards: CALN1; OMA:CALN1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CALN1
Genomic location for CALN1
Band7q11.22Start71,779,491 bp[1]
End72,447,151 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CALN1
Genomic location for CALN1
Band5|5 G1.3- G2Start130,398,296 bp[2]
End130,876,253 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • pons

  • pars reticulata

  • cerebellar hemisphere

  • Pars compacta

  • right hemisphere of cerebellum

  • entorhinal cortex

  • external globus pallidus

  • Brodmann area 46

  • middle temporal gyrus
Top expressed in
  • nucleus accumbens

  • dorsal striatum

  • olfactory tubercle

  • facial motor nucleus

  • deep cerebellar nuclei

  • cerebellar cortex

  • globus pallidus

  • cerebellar vermis

  • lobe of cerebellum

  • temporal lobe
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

83698

140904

Ensembl

ENSG00000183166

ENSMUSG00000060371

UniProt

Q9BXU9

Q9JJG7

RefSeq (mRNA)

NM_001017440
NM_031468
NM_001363460

NM_021371
NM_181045

RefSeq (protein)

NP_001017440
NP_113656
NP_001350389

NP_067346
NP_851388

Location (UCSC)Chr 7: 71.78 – 72.45 MbChr 5: 130.4 – 130.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-binding protein 8 is a protein that in humans is encoded by the CALN1 gene.[5][6] Alternative splicing results in multiple transcript variants.[6]

Function

This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183166 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060371 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu YQ, Lin X, Liu CM, Jamrich M, Shaffer LG (Apr 2001). "Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily". Molecular Genetics and Metabolism. 72 (4): 343–50. doi:10.1006/mgme.2001.3160. PMID 11286509.
  6. ^ a b "Entrez Gene: CALN1 calneuron 1".
  7. ^ McCue HV, Haynes LP, Burgoyne RD (Aug 2010). "The diversity of calcium sensor proteins in the regulation of neuronal function". Cold Spring Harbor Perspectives in Biology. 2 (8): a004085. doi:10.1101/cshperspect.a004085. PMC 2908765. PMID 20668007.

External links

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
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