Protein-coding gene in the species Homo sapiens
| ANGPTL1 |
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| Identifiers |
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| Aliases | ANGPTL1, ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2, angiopoietin like 1 |
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| External IDs | OMIM: 603874; MGI: 1919963; HomoloGene: 128467; GeneCards: ANGPTL1; OMA:ANGPTL1 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1q25.2 | Start | 178,849,535 bp[1] |
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| End | 178,871,077 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1|1 G3 | Start | 156,666,132 bp[2] |
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| End | 156,688,648 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - left uterine tube
- smooth muscle tissue
- Achilles tendon
- popliteal artery
- left coronary artery
- synovial membrane
- synovial joint
- pancreatic epithelial cell
- gastric mucosa
- right coronary artery
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| | Top expressed in | - basilar part of occipital bone
- intercostal muscle
- squamous epithelium
- condyle
- mesothelium
- rib
- sphenoid bone
- dermis
- lesser wing of sphenoid bone
- soleus muscle
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - signaling receptor binding
| | Cellular component | - extracellular exosome
- extracellular region
- extracellular space
| | Biological process | - transmembrane receptor protein tyrosine kinase signaling pathway
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 1: 178.85 – 178.87 Mb | Chr 1: 156.67 – 156.69 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.[5][6][7]
Function
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels.
The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116194 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033544 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353–6. doi:10.1016/S0014-5793(99)00008-3. PMID 10025962. S2CID 27230019.
- ^ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.
- ^ a b "Entrez Gene: ANGPTL1 angiopoietin-like 1".
External links
Further reading
- Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS (2005). "Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties". Biochem. Biophys. Res. Commun. 333 (2): 308–15. doi:10.1016/j.bbrc.2005.05.134. PMID 15950186.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi:10.1073/pnas.96.5.1904. PMC 26709. PMID 10051567.
- Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
- Kim I, Moon SO, Koh KN, et al. (1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J. Biol. Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614.
- Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
- Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi:10.1096/fj.03-1466com. PMID 15284220. S2CID 19001234.
- Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi:10.1016/j.ccr.2004.09.030. PMID 15542434.
- Smagur A, Szary J, Szala S (2006). "Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours". Acta Biochim. Pol. 52 (4): 875–9. doi:10.18388/abp.2005_3401. PMID 15940350.
