ARID4B

Protein
ARID4B
Identifiers
AliasesARID4B, BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180, AT-rich interaction domain 4B
External IDsOMIM: 609696; MGI: 2137512; HomoloGene: 12847; GeneCards: ARID4B; OMA:ARID4B - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ARID4B
Genomic location for ARID4B
Band1q42.3Start235,131,634 bp[1]
End235,328,219 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for ARID4B
Genomic location for ARID4B
Band13 A1|13 5.29 cMStart14,237,817 bp[2]
End14,374,188 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Epithelium of choroid plexus

  • sperm

  • parietal pleura

  • visceral pleura

  • epithelium of nasopharynx

  • tibia

  • Achilles tendon

  • germinal epithelium

  • sural nerve

  • buccal mucosa cell
Top expressed in
  • tail of embryo

  • ascending aorta

  • aortic valve

  • medullary collecting duct

  • supraoptic nucleus

  • genital tubercle

  • cumulus cell

  • trigeminal ganglion

  • ganglionic eminence

  • blood
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • histone deacetylase activity
  • molecular function
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • nucleoplasm
  • nucleus
  • cellular component
Biological process
  • regulation of gene expression by genetic imprinting
  • regulation of transcription, DNA-templated
  • establishment of Sertoli cell barrier
  • regulation of transcription by RNA polymerase II
  • histone H4-K20 trimethylation
  • transcription, DNA-templated
  • histone H3-K9 trimethylation
  • spermatogenesis
  • positive regulation of transcription by RNA polymerase II
  • histone deacetylation
  • biological process
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51742

94246

Ensembl

ENSG00000054267

ENSMUSG00000039219

UniProt

Q4LE39

A2CG63

RefSeq (mRNA)

NM_001206794
NM_016374
NM_031371

NM_194262
NM_198122

RefSeq (protein)

NP_001193723
NP_057458
NP_112739

NP_919238
NP_937755

Location (UCSC)Chr 1: 235.13 – 235.33 MbChr 13: 14.24 – 14.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[5][6]

Function

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054267 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
  6. ^ a b "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".

External links

Further reading

  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
  • Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
  • Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. doi:10.1158/1055-9965.1136.13.7. PMID 15247124. S2CID 28408982.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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