ABI1

Protein-coding gene in the species Homo sapiens
ABI1
Identifiers
AliasesABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1
External IDsOMIM: 603050; MGI: 104913; HomoloGene: 38053; GeneCards: ABI1; OMA:ABI1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ABI1
Genomic location for ABI1
Band10p12.1Start26,746,593 bp[1]
End26,861,087 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ABI1
Genomic location for ABI1
Band2 A3|2 15.18 cMStart22,830,085 bp[2]
End22,930,253 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of nasopharynx

  • amniotic fluid

  • palpebral conjunctiva

  • cartilage tissue

  • oral cavity

  • bronchial epithelial cell

  • skin of arm

  • bone marrow

  • thymus

  • mucosa of paranasal sinus
Top expressed in
  • mesenteric lymph nodes

  • subiculum

  • granulocyte

  • lateral septal nucleus

  • left lung lobe

  • parotid gland

  • lobe of cerebellum

  • skin of external ear

  • anterior amygdaloid area

  • ventral tegmental area
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein tyrosine kinase activator activity
  • protein-containing complex binding
  • cytoskeletal protein binding
  • protein binding
  • SH3 domain binding
  • cadherin binding
Cellular component
  • cytoplasm
  • cytosol
  • postsynaptic membrane
  • cell projection
  • postsynaptic density
  • SCAR complex
  • membrane
  • filopodium
  • growth cone
  • plasma membrane
  • synapse
  • intracellular anatomical structure
  • cell junction
  • cell leading edge
  • endoplasmic reticulum
  • neuron projection
  • extracellular exosome
  • cytoskeleton
  • nucleus
  • lamellipodium
  • filopodium tip
Biological process
  • somitogenesis
  • megakaryocyte development
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • positive regulation of protein tyrosine kinase activity
  • vascular endothelial growth factor receptor signaling pathway
  • peptidyl-tyrosine phosphorylation
  • viral process
  • lamellipodium morphogenesis
  • negative regulation of cell population proliferation
  • dendrite morphogenesis
  • actin polymerization or depolymerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10006

11308

Ensembl

ENSG00000136754

ENSMUSG00000058835

UniProt

Q8IZP0

Q8CBW3

RefSeq (mRNA)
NM_001012750
NM_001012751
NM_001012752
NM_001178116
NM_001178119

NM_001178120
NM_001178121
NM_001178122
NM_001178123
NM_001178124
NM_001178125
NM_005470
NM_001348029
NM_001348030
NM_001348031
NM_001348032
NM_001348033
NM_001348034

NM_001077190
NM_001077192
NM_001077193
NM_007380
NM_145994

NM_001331043
NM_001331044
NM_001331045
NM_001377510
NM_001377511
NM_001377512
NM_001377513

RefSeq (protein)
NP_001012768
NP_001012769
NP_001012770
NP_001171587
NP_001171590

NP_001171591
NP_001171592
NP_001171593
NP_001171594
NP_001171595
NP_001171596
NP_005461
NP_001334958
NP_001334959
NP_001334960
NP_001334961
NP_001334962
NP_001334963

NP_001070658
NP_001070660
NP_001070661
NP_001317972
NP_001317973

NP_001317974
NP_031406
NP_666106
NP_001364439
NP_001364440
NP_001364441
NP_001364442

Location (UCSC)Chr 10: 26.75 – 26.86 MbChr 2: 22.83 – 22.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.[5][6]

Function

Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.[7]

Abi1 is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization. Furthermore, Abi1 is a component of the WAVE complex. Some research has shown that knockdown of Abi1 by siRNA promoted degradation of WAVE complex proteins.[citation needed]

Interactions

ABI1 has been shown to interact with

ENAH,[8] NCKAP1,[9] EPS8,[6][8][9][10][11] and SOS1.[12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136754 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058835 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem. 273 (22): 13681–92. doi:10.1074/jbc.273.22.13681. PMID 9593709.
  6. ^ a b Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.
  7. ^ "Entrez Gene: ABI1 abl-interactor 1".
  8. ^ a b Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
  9. ^ a b Yamamoto A, Suzuki T, Sakaki Y (June 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
  10. ^ Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G (January 2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
  11. ^ Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (November 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
  12. ^ Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP (September 1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID 10499589. S2CID 205045006.

Further reading

  • Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
  • Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases". Int. J. Biochem. Cell Biol. 34 (10): 1178–83. doi:10.1016/S1357-2725(02)00064-X. PMID 12127568.
  • Cardwell C (1977). "Student or worker? International Meeting of Student Nurses (European Group)". Nursing Mirror and Midwives Journal. 143 (19): 38. PMID 1049958.
  • Biesova Z, Piccoli C, Wong WT (1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.
  • Taki T, Shibuya N, Taniwaki M, et al. (1998). "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)". Blood. 92 (4): 1125–30. doi:10.1182/blood.V92.4.1125. PMID 9694699.
  • Scita G, Nordstrom J, Carbone R, et al. (1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID 10499589. S2CID 205045006.
  • Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551. S2CID 7370589.
  • Fan PD, Goff SP (2000). "Abl Interactor 1 Binds to Sos and Inhibits Epidermal Growth Factor- and v-Abl-Induced Activation of Extracellular Signal-Regulated Kinases". Mol. Cell. Biol. 20 (20): 7591–601. doi:10.1128/MCB.20.20.7591-7601.2000. PMC 86315. PMID 11003655.
  • Xu J, Ziemnicka D, Merz GS, Kotula L (2001). "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells". J. Cell Sci. 113 (21): 3805–14. doi:10.1242/jcs.113.21.3805. PMC 4511602. PMID 11034908.
  • Lanzetti L, Rybin V, Malabarba MG, et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
  • Yamamoto A, Suzuki T, Sakaki Y (2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
  • Cowan CA, Henkemeyer M (2001). "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals". Nature. 413 (6852): 174–9. Bibcode:2001Natur.413..174C. doi:10.1038/35093123. PMID 11557983. S2CID 4313061.
  • Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
  • Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
  • Morerio C, Rosanda C, Rapella A, et al. (2003). "Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?". Cancer Genet. Cytogenet. 139 (1): 57–9. doi:10.1016/S0165-4608(02)00616-7. PMID 12547160.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.

External links



  • v
  • t
  • e